Sentence examples for many proinflammatory mediators from inspiring English sources

These MAPKs play important roles in the stimulation of the inflammatory response by increasing the expression of many proinflammatory mediators [9], [10].

IL-1β is also known to stimulate many proinflammatory mediators in a variety of cell types [ 32].

Moreover, many proinflammatory mediators like cytokines and BK induce the expression of MMP-9 during brain injury by increasing ROS production [ 25, 62].

Under pathological conditions, many proinflammatory mediators like bradykinin (BK) induce expression of several inflammatory genes during brain injury by increasing ROS production [ 7, 10].

For instance, the switching phenotype could be involved in the reprogramming of the pathologic M2 phenotype under conditions when many proinflammatory mediators are in the tumor microenvironment.

Although glucocorticoid does prevent inflammation by suppressing production of many proinflammatory mediators, including cytokines such as IL-1 β and TNF- α, it also induces apoptosis in immature and mature T lymphocytes.

Many upregulated proinflammatory mediator messages in ligated SMGs (Supplementary Figure S2) are also genes encoding SASP factors that are secreted by various cells undergoing premature senescence.

Among these, NF- κB has been reported to play a vital role in mediating cell survival and the upregulation of many cytokines and proinflammatory mediators essential to the host and ERK1/2 has been reported to mediate transcription of proteases and cytokines in response to an array of stimuli, including cigarette smokers [ 52].

Intermediate (CD14+CD16+) and non-classical or inflammatory (CD14+CD16++) subsets produce large amounts of proinflammatory mediators and are up-regulated in many inflammatory disorders, such as rheumatoid arthritis, atherosclerosis, bacterial sepsis and various hepatic diseases.

These different cell types release a plethora of growth factors and proinflammatory mediators including cytokines and reactive oxygen species, many of which are involved in growth regulation of the epithelial cell compartment of the tissue.

During mast cell activation, many signaling molecules are engaged in diverse responses, ranging from calcium release from internal stores, degranulation, the generation of lipid-derived proinflammatory mediators and the production of cytokines and chemokines.