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The strength of this model stems from the extraction of ancestral structure from many probe sites per tumor, potentially utilizing measurements of the expression or copy number changes across the entire genome.
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The binding sites for many probes are ambiguous either because two sites have identical sequences or the predicted Δ G° for a probe binding an alternative site with a mismatch is more favorable than −8 kcal/mol and RNRspBs binds moderately or strongly to the probe with perfect complementarity to the site.
As a result, a cryptic initiation site of a given magnitude is more likely to be detected in longer genes containing many probes than in shorter genes with relatively few probes.
The key problem many probes encounter is the issue of selectivity, since 23 human MMPs, despite playing different physiological roles, have structurally similar active sites.
"How many probes have we sent to the other planets?
There are many probing, even indiscreet, moments in Goldstone's 1975 book, subtitled "An Intimate Portrait".
There aren't that many probes used (46 genes).
By designating AFAS probes to human-mouse orthologous genes, we identified many probes showing positive signals.
Try an alternative probe site.
Many government sites now offer agritourism opportunities.
So many strange sites to be seen!
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com