Many predictive factors of response have been studied, and several authors have reported that hormone receptor negativity, high histological grade and high Ki-67 levels correlate with pCR, while the predictive value of Her 2 expression, bcl-2 and p53 status is still unclear (Archer et al, 1995; Makris et al, 1997; Chang et al, 1999; Colleoni et al, 1999; Ellis et al, 2001; Petit et al, 2001).
On the other hand, neonatal prognosis is conditioned by many independent predictive factors (birth weight, use of steroids before birth, multiplicity of pregnancy) [ 18].
Using restricted follow-up data until 1, 2, and 3 years of follow-up, many independent predictive factors changed with follow-up duration, but surgical category could be universal and independent predictive factors.
Investigation of survivors at 1, 2, and 3 years of follow-up showed that many independent predictive factors were not universal at any follow-up period and changed accordingly.
Many studies on predictive factors of recurrence have been carried out in NSCLC of various pathological stages.
We expect that many of the predictive factors studied (age, location, specialist type and practice arrangements) have remained relatively stable over time.
In patients diagnosed with an advanced stage of RCC with a tumor thrombus, many important independent predictive factors were identified in each subgroup analysis in terms of restricted follow-up duration and yearly-based survivors.
Many studies have introduced predictive factors potentially associated with chronic GI complications after RT for gynecologic malignancies [ 14– 14].
Although many studies have identified predictive factors of clinical response to biologic agents, few have been confirmed, in particular for abatacept [ 10].
The approach to treatment within breast cancer subtypes greatly simplifies the definition of therapy indications, since the subtypes themselves incorporate many of the risk and predictive factors used in previous consensus recommendations.
However, the steroid receptor status of the primary tumour does not fully predict which patient will benefit or fail from endocrine therapy, and many more potential cell biological predictive factors have been studied (reviewed by Klijn et al, 1999, 2002).
