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Many preclinical studies demonstrated the antitumor effects of Thl cytokines but their clinical efficacy is limited.
This particle has been used in many preclinical studies and is evaluated for a further phase I clinical trial.
As it is quite complex to study responses of metastases in a preclinical model, there have not been many preclinical studies on therapies in metastatic models.
Although genetically modified mice are powerful tools to investigate the molecular basis of many human diseases, they are less suitable for many preclinical studies.
During the last decade, many preclinical studies have been evaluating new near-infrared fluorescent probes for targeted molecular imaging, and the trend is to slowly move towards the translation into clinical practice.
Although many preclinical studies have suggested the possible linkage between dyslipidemia and cerebral amyloid deposition, the association between serum lipid measures and cerebral amyloid-beta (Aβ) deposition in human brain is still poorly known.
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In addition, there is nothing restricting such plots to human clinical data and they would also be suitable for many preclinical animal studies.
Moreover, many earlier preclinical studies performed on xenografted tumours (for review see Gerber and Ferrara, 2005) demonstrated an effect of bevacizumab on tumour growth.
Importantly, the development of tumor-targeted probes for optical imaging has encouraged many researches in the last 10 years, leading to many recently published preclinical studies.
Capsaicin was used as the stimulus as this substance has been used in many preclinical migraine drug studies previously [41, 42].
We conclude that the results of many basic and preclinical studies indicate that bioengineered tissue can be adapted to conventional surgical techniques.
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