Among their many functions, these lipids are potent inflammatory modulators and thus have been associated with responses to cardiovascular diseases, host defense, tissue injury, and surgical intervention [ 1– 3].
For many years, studies on the biological effects of PAF as a potent inflammatory mediator were mainly been focused on the activation of cells involved in inflammation.
Triazine is found in many potent biologically active molecules with promising biological potential like anti-inflammatory, anti-mycobacterial, anti-viral, anti-cancer etc. which makes it an attractive scaffold for the design and development of new drugs.
TNFα is a potent inflammatory activator of endothelial cells [23] and is critical to the pathogenesis of many inflammatory diseases, most notably rheumatoid arthritis [24].
The end products are highly potent inflammatory mediators.
It degrades primary amines and produces hydrogen peroxide, ammonium and aldehyde as its enzymatic end products - all potent inflammatory mediates.
Among PGD2 metabolites, 15d-PGJ2 exhibited most potent inflammatory effects [4].
IL-6 is a cytokine with potent inflammatory properties and metabolic effects in SMCs.
S100A12 has potent inflammatory effects.
Larger indices indicate a more potent inflammatory or inhibitory potential.
