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This indicates considerable variation among replicated plant bioassays for many populations, which translates into uncertainty in the estimated resistance score.

Previous studies in Iran (Cook-Mozaffari et al, 1979; Ghadirian et al, 1985) avoided using questionnaires to ask about opium use, partly because it can be a sensitive subject in many populations, which may limit the validity of questionnaire responses.

Remarkably, defects in one locus (DFNB1) account for up to 50% of cases in many populations, which makes this the most common cause of non-syndromic, prelingual hearing impairment and deafness.

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We hypothesise that such a pattern could have been produced by rapid and complex evolution involving a widespread progenitor for which an initial split into two groups was followed by subsequent fragmentation into many diverging populations, which was followed by range expansion of then divergent entities.

Access to ACTs, however, is still limited for many populations, amongst which traditional methods remain the primary source of care.

Many populations for which we had time series information were also included in our genetic analysis, making stock assignments unambiguous (Table 1).

Although quite small for linkage map generation, this population is typical of many cacao mapping populations, which are often studied in regions where resources are limited.

Highly polymorphic genes are, by definition, prone to display numerous, extremely diverse variants as well as many heterozygotes within populations, which can hardly be genotyped using direct sequencing.

Also, some projected climatic conditions such as heat waves are of a duration or intensity not previously experienced by many (researched) human populations, which presents challenges to the estimation of future risk.

Many studies omit disadvantaged populations which are known to have higher levels of smoking [ 10].

Now the authors state in their rebuttal letter that they don't want to examine actin assembly rates in adhesions because they "contain many different actin filament populations", which makes it "difficult to follow vectorial actin polymerization if the photobleaching is performed at the actual adhesion".

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