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We recommend a more widespread use of these straightforward approaches (and related techniques), in order to promote a greater awareness of the limitations of many population analyses.
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Although this reflects the size and distribution of the population, many population genetic analyses are influenced by sample size, including linkage disequilibrium and founder effects.
Tracts of identical-by-descent (IBD) may reflect the sampling of related individuals and can contradict theoretical assumptions and complicate many population genetic analyses.
As with many viral population analyses, the first step of VGA is to map the reads.
As with many population-based analyses, this study has a number of limitations.
Many population genetic and phylogenetic analyses of mitochondrial DNA (mtDNA) assume that mitochondrial genomes do not undergo recombination.
Capillary sequencing is rate-limiting for large population analyses of many genes, so it can be efficient to focus such analysis on genes with more than a minimal amount of polymorphism, and for P. falciparum initial screening can now be performed using emerging genome sequence diversity data, accessible through PlasmoDB (www.plasmodb.org) [5] [7].
The rigorous nature of many population genetics models and their extensive analysis has lead to key insights in analysing genomic sequences [ 2, 60- 64].
Atomic charges were derived by natural [30] population analyses.
Elevated genotypic diversity in many populations resulted in uninformative results for some MLG diversity statistics, as was seen in previous analyses of soybean aphid populations (Michel et al. 2009; Orantes et al. 2012).
Fig. 1 Flow-chart of the population analysed.
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