Sentence examples for many physiological substrates from inspiring English sources

AKT activation stimulates cell cycle progression, survival, metabolism and migration through phosphorylation of many physiological substrates [19] [21], [21].

In contrast to the minimal furin recognition motif Arg-X-X-Arg which is cleaved after the C-terminal arginine residue, the optimized furS cleavage site contains an additional C-terminal serine residue which is present in many physiological substrates of furin [26], and resides at the N-terminus of the cleavage product after processing (Fig. 5A).

MMPs and ADAMs have been intensively studied and many physiological substrates, inhibitors and regulatory molecules have been identified that demonstrate the biological importance of these enzymes [ 14– 16].

In addition to the main physiological substrates tyrosine and BH4, TH can utilize alternative amino acid substrates (Fig. 1) and many synthetic BH4 derivatives [Teigen et al., 2004].

Perturbation of the NMD mechanism may have major implications as a result of altered levels of many of its physiological substrates.

CD44 plays a major role in many physiological processes, including cell substrate, interaction cell-cell adhesion, lymphocyte homing, and tumor metastasis.

MDR-1 Pgp in HK-2 appears to be responsive to many compounds, including classical Pgp inhibitors and putative physiological substrates, but some of its pharmacological properties are different from those described in other experimental, in particular nonhuman, cell models.

These extracellular kinases phosphorylate cell-surface proteins and soluble extracellular substrates, and thus could affect many physiological processes involving cell-cell contacts, cellular differentiation and proliferation, ion transport [ 82].

Next, we investigated what the consequence of mono-ADP-ribosylation is for the ARTD10 substrate GSK3β, a kinase that controls many physiological processes.

The enzyme γ-glutamyl transpeptidase (GGT), implicated in many physiological processes, catalyses the transfer of a γ-glutamyl from a donor substrate to an acyl acceptor substrate, usually an amino acid or a peptide.

Although DPP-IV has many substrates in vitro, relatively few have so far been found to be physiological substrates in vivo [ 6].