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Calcineurin is a serine/threonine protein phosphatase that plays a critical role in many physiologic processes such as T-cell activation, apoptosis, skeletal myocyte differentiation, and cardiac hypertrophy.
Chloride is the body's most important extracellular anion, important in many physiologic processes including acid base balance and osmotic pressure [1].
As it may affect many physiologic processes and responses, hypothermia itself is commonly suspected to promote these events (Fig. 2) [87].
COX-1 is found in most tissues and plays a role in homeostasis of many physiologic processes.
As it may affect many physiologic processes and responses, hypothermia itself is commonly suspected to promote these events (Fig. 2) [ 87].
The PI3K signaling pathway is involved in cellular processes such as cell survival, proliferation and apoptosis, and in many physiologic processes [ 7, 8].
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The PI3K/Akt pathway is an important regulator of many key physiologic processes and the development of several classes of Akt inhibitors has been halted because of toxicity [19], [20].
The Fas-FasL system is a primary mediator of apoptosis in many major physiologic processes.
It is now well established that miRNAs play essential roles in many basic physiologic processes including proliferation, differentiation, and apoptosis.
Angiogenesis plays important roles in many physiologic and pathologic processes in the body.
Recent advances have implicated the adipocyte in many physiologic and pathologic processes, such as obesity, diabetes, cardiovascular disease and muscular disorders [1].
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