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Second, because of the complexity of protein interactions in many physiologic pathways in the brain, it is still unclear which is the key protein in the development of CRPS.
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The WNT pathway participates in many physiologic events in embryogenesis and adult homeostasis including cell fate specification, control of proliferation, and migration.
The MAP kinase family comprises extracellular-signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK), and these signal pathways have been implicated in many physiologic processes, including cell growth and death through p53-dependent or p53-independent mechanisms [ 6].
The PI3K signaling pathway is involved in cellular processes such as cell survival, proliferation and apoptosis, and in many physiologic processes [ 7, 8].
Ongoing research efforts are focusing on the biological and physiologic pathways that cause or contribute to the development of anergia.
Unlike conventional analyses, this multivariate approach identified distinct groups of genes that are plausibly linked in physiologic pathways, perhaps epistatically.
In just three weeks, these 20-year-olds developed many physiologic characteristics of men twice their age.
Therapeutic interventions might improve with knowledge of the physiologic pathways involved in the hyperplastic response to vascular injury.
Apoptosis, often defined as programmed cell death, plays a very important role in many physiologic and pathologic conditions.
Although genetic abnormalities may have moderate effects, the physiologic pathways involving these genes have redundant compensating mechanisms to bring the system back into equilibrium.
BACKGROUND: Interleukin-6 (IL-6) contributes to numerous inflammatory, metabolic, and physiologic pathways of disease.
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