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These changes are caused by the many physiologic changes that occur during pregnancy (eg, altered hormone levels, increased urination at night, changes in body size) and post partum, especially with a newborn to tend.
We speculate that early homeostatic changes after human conception and early embryonic development may affect chemical mobilization from lipid reserves, possibly as a result of the many physiologic changes accompanying pregnancy (Bernstein et al. 2001) that may affect the absorption, distribution, metabolism, and excretion of exogenous compounds (Casarett et al. 1996).
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This is not surprising given the many physical and physiologic changes during pregnancy.
Many mammals exhibit distinct physiologic changes with the changing seasons, typically timed to the light-dark cycle and mediated by melatonin (humans exhibit some such changes) (8 – 11 ).
Animals undergo substantial changes in many physiologic and biochemical functions as a natural consequence of aging.
The pharmokinetics of many drugs can be altered due to the physiologic changes following major burns.
The morphologic and physiologic changes observed in the elderly affect many organ systems and cause several disorders.
The interactions of many of these medications are unknown, but recent research has shown the possibility of many harmful interactions, especially in older adults who have physiologic changes that impact medication clearance and pharmaco-dynamics [ 18].
The elderly maybe more susceptible to adverse drug events and drug-drug interactions (DDIs) due to gradual age-related physiologic changes that affect the pharmacokinetic and pharmacodynamic properties of many medications [ 1368, 1369].
Although many physiologic systems are influenced by acute and chronic stress, there is relatively little consensus on optimal biomarkers to capture physiologic changes with acute or chronic stress.
As we don't have too many bears running wild today, but we do have increased exposure to new substances, and increased ability to assess physiologic changes, current investigators use emulsifiers and mice intestines, as opposed to bears chasing humans.
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