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To determine how many phenotypic groups existed within the HS colony, a K-means cluster analysis was conducted.
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A principal component analysis revealed two main phenotypic groups, partially correlating with previously described genomic clusters.
However, it is remarkable that the differential expression patterns between the phenotypic groups included so few genes, and that so many of these were physically clustered.
They are composed of different groups of cells that display a remarkable variability in many phenotypic traits, including different metastatic abilities and survival ability after therapy.
Among the other phenotypic groups, there was one comprising 4 genes that led to a relatively low Fringe-GFP signal in many cells, small-sized and seemingly fragmented tER-Golgi units, and higher levels of PDI (Figure 3E F; Table S2;).
Many SNPs, deletions, IS movements and short indels have been identified that explained the functional changes that occurred in different phenotypic groups [ 19, 27].
This model recapitulates many phenotypic features of WS.
They have similarity in many phenotypic features except motility.
We conclude that although low-count MBL share many phenotypic characteristics with CLL, many MBL are oligoclonal.
Since human NP cells lose many phenotypic characteristics with age, attachment and interaction with the ECM may be altered.
Convergent mutations in promoters and enhancers have been the basis for many phenotypic changes in evolution (Wray 2007).
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