It is characterized by many phenotypes, including wide anterior fontanel, frontal bossing of the face, depressed nasal bridge, along with the 4 classic phenotypes contained in the name of the syndrome.
In both plants and animals, small genomes are associated with many phenotypes, including small nuclei, small cells, short cell cycles, high metabolic or photosynthetic rates, rapid growth, and short generation time (Gregory 2002, 2005; Cavalier-Smith 2005; Knight et al. 2005; Dufresne and Jeffery 2011).
Growth arrest is associated with many positive phenotypes including increased productivity, sustained viability and an extended production phase.
Emerging literature has highlighted the influence of cell topography interactions on modulation of many cell phenotypes, including protein expression and cytoskeletal behaviors implicated in endocytosis.
Emerging literature has highlighted the influence of cell-topography interactions on modulation of many cell phenotypes, including protein expression and cytoskeletal behaviors implicated in endocytosis.
Genetic knockout of one App allele in the Fmr1 KO mice rescues many disease phenotypes including seizures, anxiety, the ratio of mature versus immature dendritic spines and mGluR-LTD [20].
Compared to other deubiquitinating enzyme mutants, a ubp5Δ mutant exhibited severely attenuated virulence and many distinct phenotypes, including decreased capsule formation, hypomelanization, defective sporulation, and elevated sensitivity to several external stressors (such as high temperature, oxidative and nitrosative stresses, high salts, and antifungal agents).
We report here that many Myc phenotypes, including the Warburg effect and enhanced OXPHOS, can be genetically uncoupled.
A promoter variant in this transporter found upstream of the region that we analyzed has been associated with many clinical phenotypes including depression and suicide [35].
DS patients present many clinical phenotypes including intellectual disability and an apparent decreased risk of certain cancers including gastrointestinal cancers (39, 40, 63).
In terms of phenotyping, we recommend that future studies assay many more phenotypes, including molecular and biochemical traits (e.g., blood levodopa levels), in addition to high-level Boolean phenotypes such as case/control status.
