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As the pain was continuous, many patients felt reminded on the ulceration [ 9].
We observed a similar pattern of adverse events and a continued need to decrease the dose of sorafenib to 200 mg once daily, although not in as many patients as with the continuous daily dose schedule.
Despite early and continuous treatment many patients with phenylketonuria (PKU) still experience neurocognitive problems.
Acute kidney injury (AKI) is increasingly common in critically ill patients and many patients with severe kidney injury require continuous renal replacement therapy (CRRT).
However, it is important that such additional treatments are themselves well tolerated and effective for long periods of time given that many patients with chronic inflammatory conditions require continuous NSAID therapy for many years.
There is a trend towards an increase in the number of patients requiring RRT with pulse CPA therapy, with twice as many patients requiring dialysis on this treatment compared to continuous treatment.
This is the perceived dilemma faced by many patients diagnosed with obstructive sleep apnea (OSA) and prescribed continuous positive airway pressure (CPAP).
Based on the clinical and safety data obtained in this 3-year clinical study, continuous efalizumab therapy represents an appropriate treatment for long-term therapy for many patients with plaque psoriasis.
In Europe, studies with continuous high-dose IL-2 i.v. infusion led to even more toxicity; many patients required admission to the intensive care unit (ICU) and some patients succumbed to this treatment.
The other three tables were from the 12 papers that had a "continuous" primary outcome measure that had between five and nine possible values and presented how many patients achieved each value.
These findings suggest that the dynamics of depression over time differ across patients, with many patients showing more or less abrupt transitions from one state to the other and others showing more continuous variation in depression severity over time.
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