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As expected, many pathways related to cell growth and proliferation, cell death and cell cycle are represented.
Indeed, miRNAs have been found to play a role in most, if not all, cellular processes, including many pathways related to cancer development and progression.
Its genome has retained many pathways related to the biosynthesis of B-vitamins, pointing toward a role in supplementing the blood-restricted diet of its host.
Corresponding to the gene expression pattern of integrins, gene signature analysis showed the presence of many pathways related to the interaction between integrins and ECM in MDCK-Ras cells.
When analyzing the biological functions of the genes differentially expressed upon infection, it was evident that the infection produced a detrimental effect on many pathways related to growth and normal metabolism, as genes related to protein synthesis, protein degradation, small molecule biochemistry, lipid metabolism, cancer and carbohydrate metabolism were down-regulated.
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Plant diurnal oscillation is universal for plants and coordinates many biological pathways related to extracellular or intracellular signals, adapting the plants to daily alternation and maintaining a balance between metabolic reactions during light and darkness, especially for fluctuations of the carbon balance [1], [2], [3], [4], [5], [6], [7], [8], [9], [10].
These results suggested that bud dormancy involves many biochemical pathways related to photoperiod, temperature, circadian clocks, water, energy, reactive oxygen species, and hormones.
Gene Ontology (GO) and KEGG Pathway analysis of the differentially expressed genes revealed enrichment for many categories and pathways related to macrophage function, suggesting the differentiation had been successful (Fig. 2d).
Although the list of uncorrected P-values (RAW) contained many genes and pathways related to asthma, the results possessed a potential high false positive rate (16,015 x 0.05 = 800 theoretical false positives).
In the current study, the expression of many proteins and pathways related to defense genes, such as cell wall synthesis, beta glucanase PR-proteins, proteolysis and secondary metabolites, were gradually upregulated in early germination, which could protect germinating seeds from the damages of biotic and abiotic stresses (Additional file 9: Figure S4).
Among more general pathways (protein ubiquitination pathway, mitochondrial pathway), many pathways were related to the immune system (T cell activation, B cell activation) indicating the immune-specificity of the starting cells.
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