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These observations demonstrated how many pathways overlap, with dysregulation of one pathway potentially impacting another.
Recognizing that many pathways overlap in both their methodologies and disciplinary approaches, we encouraged the first set of reviewers to be liberal in their application of codes and inclusion or exclusion of citations that they deemed relevant to the eight categories.
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In many respects, L-cell stimulus secretion-coupling pathways overlap with those found in pancreatic β-cells.
Though several pathways find out significantly perturbed genes [ 16– 18], unfortunately, knowledge of pathways remains incomplete, and many pathway databases contain overlap and unavailable data.
Although this report does not investigate the role of NDRG1 in secretory pathways, it may not be surprising if NDRG1 also has secretory functions as many proteins of the endocytic and exocytic pathways overlap [15], [36].
Overall, 8 of the statistically significantly enriched pathways overlap between OCCs and OCSCs (highlighted in red in Figure 5), indicating that many of the changes caused by the metabolic perturbations are similar between the two cells.
The global village simply has too many pathways.
TGFβ upstream regulates many pathways.
Many pathways are under investigation.
Many of them overlap with pathways associated with hepatic progenitor cells.
Our data also support the observation that responses to many pathogens overlap substantially with senescence signalling pathways and the existence of regulators common to both programs has previously been proposed [29].
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