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This view forgets that haemostasis is mandatory to survive sepsis via many pathways, including newly recognised immunothrombosis and HDPs.
Many pathways including transcription, replication, DNA repair, signaling and chromosome tethering require an intact nuclear lamina network [2], [5] [8].
RhoA activation triggers many pathways including Rho-associated protein kinase (ROCK) responsible for actin polymerization required for cell locomotion [ 26].
Compartmentalization of the human cell allows better control of function and reactions steps in many pathways, including ribosome assembly.
Based on the annotations of their Arabidopsis homologs, the functions of these predicted novel miRNA targets are involved in many pathways including development and signaling.
GSK-3β has several downstream targets and is a regulator in many pathways, including Wnt, PI3K and Hedgehog signaling (104– 104).
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Many of these genes have fundamental roles in many cellular pathways, including DNA repair (e.g., hMLH1, O6-MGMT) and cell cycle control (e.g., p16INK4a) (Portela and Esteller 2010).
The insulin-signaling pathway activates a powerful gene regulator that controls many genetic pathways, including some that govern metabolism.
Cytosolic and nuclear iron-sulfur (Fe-S) proteins are involved in many essential pathways including translation and DNA maintenance.
AMPK activation restores energy homeostasis at the cellular and organismal levels7 by many different pathways, including via inhibition of the mechanistic target of rapamycin (mTOR 8, a conserved serine-threonine kinase involved in nutrient sensing, growth and proliferation9, 10.
Ligands of the FPR2 receptor initiate many signaling pathways including activation of phospholipase C, protein kinase C, the mitogen-activated protein kinase, and phosphatidylinositol 3-kinase/protein kinase B pathway.
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