Indeed, many signaling pathways implicated in routine surveillance themselves go awry across the spectrum of human diseases.
The basal ganglia have strong connections with associative, orbitofrontal and sensorimotor cortices and participate in many neuronal pathways implicated in motor, emotional, motivational, associative and cognitive functions (Herrero et al., 2002).
Control of apoptosis is coordinated with that of proliferation, with many signalling pathways implicated in the normal control of tissue growth involved in both processes (Danial and Korsmeyer, 2004).
Using this MCF7 system we carried out microarray experiments that revealed the absence of TopBP1 alters the expression of genes involved in many cellular pathways implicated in breast cancer, including the oestrogen signalling pathway, and the mitogen-activated protein kinase signalling network.
Although this study took place over a longer time period than the present work, it is notable that TNF ligands and IRF1 were both up-regulated in response to H5N1, and that many of the pathways implicated by Yarilina et al were active in our dataset.
1 Many pathways are implicated in the causation of both microvascular and macrovascular complications.
Ingenuity Pathway Analysis revealed that the down-regulated genes in the metastatic signature were enriched in many pathways previously implicated in metastasis, such as integrin signaling, calcium signaling, and VEGF signaling.
Fisetin is a small, orally active molecule which can act on many of the target pathways implicated in AD.
Pax3 orchestrates many of the signalling pathways implicated in the activation or repression of myogenesis by regulating effectors and also, notably, inhibitors of these pathways.
Functionally significant driver mutations affecting splicing are expected to comprise many of the same pathways implicated by protein coding mutations that are predicted to be damaging.
