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A third mechanism involving a more global and diffuse relation among multiple genes across many pathways has also been reported to occur [7].
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The relative importance of these mechanisms is unclear, but genomic studies have shown that enzymes in a pathway are likely to have a shared ancestry, suggesting that many pathways have evolved in a step-by-step fashion with novel functions created from pre-existing steps in the pathway.
Many pathways have been reported to regulate cyclin D2 level in different tissues.
Over the years, genes involved in many pathways have been shown to affect genetic recombination.
However, as many pathways have SNPs in common with other pathways, the stringent significance thresholds of traditional multiple testing correction methods are potentially over-conservative.
At present, many pathways have been reported to regulate FLC via different chromatin pathways and co-transcriptional mechanisms involving cold-induced long antisense intragenic RNA COOLAIRR) transcripts [ 8, 9].
Of note, because the coverage of the interactome is incomplete, many pathways have sparse interaction coverage, leading to fewer enriched gene sets detected by PIPA relative to HGA.
Although many pathways have shown overarching conservation among the regenerative tissues, further exploration of tissue specificity and conservation of miRNAs among the regenerative organs may provide better knowledge of regenerative mechanisms.
MYB and WD40-repeat proteins contributed to the extensive modification and regulation of various secondary compounds in many pathways have been validated to be key roles in anthocyanin biosynthesis by regulating anthocyanin structural genes [ 48].
The involvement of ERM proteins in many signaling pathways has led to study their role during development of different species.
With the advent of these tiny regulatory RNAs, the complexity of understanding the regulatory mechanisms of many important pathways has been resolved [28], [29], [30].
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