Overall, these data suggest that there is a dynamic regulation of mRNA expression during the early stages of infection and that while many pathways are induced at later times after infection (D21), mRNAs belonging to the host heat shock proteins are induced early and likely contribute to stabilization of protein induced in response to infection-related stress.
From this, they found that many pathways were enriched at several different time points.
A most remarkable finding is that many pathways were changed at 3.5 months, more than 1 year prior to the first neuropathological signs.
Many pathways were significantly enriched at one or several of the time points.
The total effect of gender is comprised of many pathways including: disease progression at initiation, retention to care, and adherence to treatment.
Dr. Evans believes that resveratrol acts on so many pathways in the cell, particularly at high doses, that it is hard to know how it is achieving any given effect, whereas the role of Aicar and GW1516 is well defined.
At present, many pathways have been reported to regulate FLC via different chromatin pathways and co-transcriptional mechanisms involving cold-induced long antisense intragenic RNA COOLAIRR) transcripts [ 8, 9].
Numerous in vitro and in vivo models, as well as novel analytical techniques for human samples, are helping to delineate the many pathways implicated in this disease, albeit at a frustratingly slow pace.
Besides, many pathways in the category of "Metabolism" were enriched at both time points in the roots.
'Functional' inactivation, which is the key concern with p53, may occur at many levels and with cross-talk between many pathways.
