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Chemokines are small heparin-binding proteins that interact with their receptors, regulating many pathophysiological responses in hematological malignancy and inflammatory diseases [ 21, 22].
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Exosomes, nanosized EVs of endosomal origin, regulate many pathophysiological processes including immune responses and inflammation, tumour growth, and infection.
RELA is a subunit of the NF-κB complex, which is a central mediator of inflammatory responses [ 36] and causes many pathophysiological conditions upon activation [ 37], including tumorigenesis and metastasis [ 38, 39].
Finally, while an important role has been well established for HIFα in many human cancers, especially for those that are highly hypoxic [ 43], and in the pathophysiological responses to hypoxia in pulmonary hypertension and myocardial ischemia [ 44], the present are the first data linking Hif1α to human CHDs to the best of our knowledge.
Melatonin (Mel) has been successfully used as a potent antioxidant against many pathophysiological states.
Recent studies suggest that the SCI and its pathophysiological responses could be altered by systemic exposure to nanoparticles.
Concussion in younger children occurs within the context of neuromaturation, with differing age-based pathophysiological responses to injury.
In this regard, osmotic stress may mimic early pathophysiological responses to infection.
In addition to their role in cellular physiology, Ras proteins are involved in many pathophysiological processes.
Platelet-activating factor (PAF) has been long believed to be associated with many pathophysiological processes during septic shock.
Since VIP is involved in many pathophysiological processes, its release suggests a putative regulatory role for MCs in skin disorders.
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