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The redox imbalance is associated with many pathologies, such as skin disease, diabetes, cancer, Leigh syndrome, and other diseases [28].
Its uptake and metabolism are sensitive biomarkers for many pathologies, such as stroke, cancer, and various forms of psychiatric/neurodegenerative diseases [65, 66].
Matrix metalloproteinases (MMPs), a class of zinc-enzymes over-activated in many pathologies, such as arthritis and cancer, can be efficiently inhibited by a variety of molecules bearing zinc-binding groups (ZBGs).
Apoptosis is also involved in many pathologies, such as cardiovascular, neurodegenerative, immunological diseases and cancer.
The success of the ABM has allowed its use for simulating many pathologies such as HIV [ 6], tumors [ 7– 9], atherosclerosis [ 10], and multiple sclerosis [ 11].
The importance of autophagy as a homeostatic and survival-promoting mechanism is indeed underscored by the demonstration of a defective autophagy in the etiology of many pathologies, such as Crohn's disease, stroke, neurodegenerative disorders and pancreatic damage [ 2].
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Astrocytes become activated in response to many CNS pathologies such as stroke, trauma, growth of tumours or neurodegenerative diseases (Pekny and Nilsson 2005).
Recently, this class of polysaccharide has come under intense study as they have been determined to be potent activators of the innate immune system in invertebrates and vertebrates, and are currently being investigated as promising pharmacological agents for fungal infections and the treatment of many debilitating pathologies such as diabetes and cancer.
The increase production of IL-1β might also mediate the development of abrupt and persistent arthralgia since this cytokine is involved in the immunopathogenesis of many arthritic pathologies such as rheumatoid arthritis [49].
miRNAs are also associated with many human pathologies such as cancer, heart diseases, diabetes, inflammatory diseases, autoimmune diseases, and Alzheimer's disease [ 1, 8– 17].
Many fundus pathologies such as retinopathy, glaucoma and age-related macular degeneration (AMD) are associated with DM. 1 3 Screening would be very important for many patients with DM and early fundus pathology, which may be almost asymptomatic.
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