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Amyloids are polypeptide aggregates involved in many pathologies including Alzheimer's disease.
Thus, these studies indicate that ER stress functions as a target in many pathologies, including acute infections and chronic neurodegenerative diseases.
Targeting TGFβ/Smad signaling is an attractive strategy for several therapeutic applications given its role as a key player in many pathologies, including cancer, autoimmune diseases and fibrosis.
The glycation of protein and nucleic acids that occurs as a consequence of hyperglycemia disrupts cell function and contributes to many pathologies, including those associated with diabetes and aging.
Abnormal GPCR function contributes to the onset of many pathologies including cancer, vascular, and neurodegenerative diseases.
They also underlie many pathologies, including cancer [ 1].
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HMGB1 has since been implicated in many other pathologies including arthritis and cancer, and many works have studied the function of extracellular HMGB1 in infectious and inflammatory disorders, its interest as a potential therapeutic target, and its role as a messenger («alarmin») when released from the nuclei of necrotic cells (for recent reviews see e.g. [6] [10]).
Remote damage is a multifactorial phenomenon in which many components become active in specific time frames and is significant in determining the overall clinical outcome in many CNS pathologies, including spinal cord injury and traumatic brain injury.
It is believed that many thyroid pathologies, including adenomas, induce angiogenesis of immature, fragile blood vessels that are prone to rupture [10, 11].
Aging is a major risk factor for many human pathologies, including cancer, diabetes, cardiovascular disorders and neurodegenerative diseases (Lopez-Otin et al., 2013).
Substrate ubiquitylation is a reversible process critical to cellular homeostasis that is often dysregulated in many human pathologies including cancer and neurodegeneration.
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