Sentence examples for many pathologies and from inspiring English sources

Carriers were targeted to intercellular adhesion molecule 1 (ICAM-1), a transmembrane glycoprotein that is upregulated in many pathologies and used as a target for intraendothelial drug delivery.

Changes in the concentration of mitochondrial matrix H2O2 have been assumed to play a central role in many pathologies and pathways in vivo.

Chloride channels are relatively unexplored as drug targets for many pathologies, and both inhibitors and activators are being developed (Verkman and Galietta, 2009).

The production of ROS (reactive oxygen species) by mammalian mitochondria is important because it underlies oxidative damage in many pathologies and contributes to retrograde redox signalling from the organelle to the cytosol and nucleus.

Many pathologies of cartilaginous and tendinous structures, which are essential representatives of these minimal perfused tissues, are understood as a result of a condition of chronic stress overdose, overburding their minimal regenerative capacity.

Oxidative stress has been implicated in many pathologies ranging from atherosclerosis and diabetes to neurodegenerative disease and cancer, and is thought to play a major role in ageing.

Members of the Nox/Duox family have emerged as [ 46, 62] key sources of oxidative stress in aging and the progression of many pathologies beyond the CNS and have been recognized as key therapeutic targets [ 63– 63].

The pre-Christmas budget decision to abolish Labor's incentives will force many pathology clinics and diagnostic imaging practices to abandon bulk billing and begin charging patients for scans and tests.

Thus, these studies indicate that ER stress functions as a target in many pathologies, including acute infections and chronic neurodegenerative diseases.

Matrix metalloproteinases (MMPs), a class of zinc-enzymes over-activated in many pathologies, such as arthritis and cancer, can be efficiently inhibited by a variety of molecules bearing zinc-binding groups (ZBGs).

Abnormal GPCR function contributes to the onset of many pathologies including cancer, vascular, and neurodegenerative diseases.