In fact, F-FDG has been successfully applied for clinical and preclinical diagnosis in many pathologic settings like cancer [ 15– 18], inflammatory diseases such as atherosclerosis [ 19– 21], arterial inflammation [ 22], psoriasis [ 23], transplantation medicine [ 24– 28], asthma [ 29, 30], and fibrosis [ 31].
In fact, this is an established clinical procedure used in many different pathologic settings such as Crohn's disease [ 35], osteomyelitis [ 36], fever of unknown origin, infection [ 37], acute appendicitis [ 38], and arterial and colonic inflammation [ 39].
It is also a critical player in many pathologic processes, most notably in neoplasia.
The dysfunction of arterial endothelial cells is a hallmark of many pathologic states including atherosclerosis and diabetes mellitus [6].
While endothelial glycocalyx is known to regulate these functions, glycocalyx has been shown to be impaired in pathologic settings leading to endothelial dysfunction.
EC injury, activation, or dysfunction is a hallmark of many pathologic states including atherosclerosis, loss of semi-permeable membrane function, and thrombosis [25].
4 8 ILCs can be subdivided into discrete populations, which accumulate in mucosal tissues in different pathologic settings.
Stroke has many pathologic factors similar to those in cardiovascular disorders.
Appropriate tracers have a great binding specificity for molecular targets, upregulated under specific pathologic settings, permitting comparison to the physiological state.
However, recent evidence suggests that EndMT can occur postnatally in a variety of pathologic settings, including cancer and cardiac fibrosis (Zeisberg et al, 2007a, 2007b).
The TRAIL/TRAIL-R system plays an important role in relevant ocular pathologic settings, such as cancers and major diabetic complications (id, retinopathy, and macular degeneration).
