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STAT6 has been demonstrated to regulate many pathologic features of lung inflammatory responses, including Th2 cell differentiation, airway eosinophilia, epithelial mucus production, and smooth muscle changes [ 55, 56].
Although sharing many pathologic features with sporadic BL, the eBL and HIV-related BL cases do have a distinct pathogenesis and gene expression.
The truth is that, by the time a knee has severe pain and shows evidence of OA on MRI, many pathologic features coexist, making it difficult to identify the single feature that causes pain.
Signal transducer and activator of transcription 6 (STand) anuclearear factor kappa B (NF- κB) have been demonstrated to regulate many pathologic features of asthma, and both are activated by IL-4 [ 26, 27].
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Many cytokines, chemokines, adhesion molecules and matrix degrading enzymes have been demonstrated to play a role in synovial proliferation and joint destruction, which are the main pathologic features of RA.
αB-R120G heterozygous and homozygous mutant mice recapitulate many of the pathologic features observed in DRM patients, including myopathy, desmin aggregates, and mitochondrial pathology [52].
Activation of the Th2 response, including production of interleukin (IL -4, IL -4 and IL-53 from Th2 cells (andubset of CD4+ T cells) and immunoglobulin (Ig) G1 or IgE from B cells, is responsible for many of Th2 pathologicellstures of allergic immune disubset [15].
Conditional deletion of the autophagy-related protein, Atg7, in the substantia nigra dopaminergic neurons recapitulates many of the pathologic features of PD [ 62].
Notably, proinflammatory IL-18 activity has been extensively examined in CIA, an accepted animal model of RA, as it shares many immunologic and pathologic features of human RA [ 68].
Given the uniformity of many of the pathologic features of the BRCA1 ER- breast cancers in this study, we think it is unlikely that this substantially affected the major findings of our study.
Despite results of randomized trials that support adjuvant radiation therapy (RT) after radical prostatectomy (RP) for prostate cancer with adverse pathologic features (APF), many clinicians favor selective use of salvage RT.
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