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Many pathogens require direct binding to, or penetration of, mucosal cells to cause pathology.
Because many pathogens require quorum sensing to produce virulence factors in response to association with a human host, the signaling pathway is a target for design of small-molecule inhibitors.
Many pathogens require several cytoskeletal modulators for efficient invasion of their host cells.
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Type IV pili are important virulence factors in many pathogens, are required for transformation and are also associated with many other functions including cell adhesion, twitching motility and biofilm formation (Tønjum & Koomey, 1997; Mattick, 2002).
The wide range of possible pathogens requires the use of many PCR conditions; this can be circumvented by using custom printed DNA microarrays.
The number of pathogens required to cause an infection varies from as few as one (for Cryptosporidium) to as many as 108 (for Vibrio cholerae).
However, in many CF centres it is generally believed that the progressive tissue damage due to chronic inflammation caused by opportunistic pathogens requires an early and promptly regular treatment employing large dosage of antibiotics.
Each of these pathogens requires different regimens".
Many key cellular bacterial components, including enzymes and small noncoding RNAs (sRNAs), and their involvement in MDR have been well studied, but exploiting such components in eradicating these pathogens requires further study.
nPositive urine culture for pathogens requiring antibiotics.
Defense against pathogens requires permanent adaptation to the changes in pathogen virulence strategies [ 31, 32].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com