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Although its etiology is not established, many pathogenic pathways are thought to contribute to tissue injury.
A common final endpoint for many pathogenic pathways is impaired nerve perfusion, hypoxia, and nerve energetic defects.
One explanation for the different effects in MS and CD may be the many pathogenic pathways that IFN beta is thought to influence in MS [ 17].
In light of the diverse responses to targeted therapies, rheumatoid arthritis might represent a final common clinical phenotype that reflects many pathogenic pathways.
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SOD1 transgenic mice and VAP mutant mice show TDP-43 pathology suggesting that many of these pathogenic pathways may be linked.
They are key enzymes in the widespread anaerobic pathway of arginine degradation and many pathogenic microorganisms use this pathway for energy production.
The PD pathogenic pathways involve defects in many cellular processes such as protein degradation, oxidative stress, phosphorylation signaling, and mitochondrial function.
The pathway is also at the epicenter of many pathogenic events including Alzheimer's disease (AD), Parkinson's disease (PD), and bacterial and viral infections.
Many pathogenic microbes have developed means to interfere with different stages of ubiquitin pathways to promote their survival and replication.
Many pathogenic bacteria utilize the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for the biosynthesis of isopentenyl diphosphate and dimethylallyl diphosphate, two major building blocks of isoprenoid compounds.
Terpenoid precursor biosynthesis occurs in human and many pathogenic organisms via the mevalonate and 2-C-methyl-d-erythritol-4-phosphate (MEP) pathways, respectively.
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