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Along with silicon, many other substrates such as glass, nickel, sapphire, quartz, and alumina have been explored in this direction [3 10].
In the present study, we show that SENP3 could remove all polySUMO2/3 conjugates from Sp1 and from many other substrates, and simultaneously remove ubiquitin conjugates.
γ-Secretase is crucial for the generation of the neurotoxic amyloid β-peptide (Aβ) but also takes part in the processing of many other substrates.
One of the major regulators of NF-κB is the E3 ubiquitin ligase SCFβ-TrCP, which targets IκB as well as many other substrates for ubiquitination and degradation, [27].
Human UDP-glucuronosyltransferase (UGT) 1A is a subfamily of UGT enzymes that glucuronidate xeno-/endobiotics and many other substrates such as steroids and bilirubin to make the metabolic products more easily excreted from the body via the urinary and biliary tracts [1], [2].
Many other substrates of SFK remain unknown.
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We have previously demonstrated that FN is the main Q-donor substrate in osteoblast matrix and accumulates in large quantities in the cells [16], however, many other cellular substrates may exist [27], [28].
Cooperative binding of two cAMP molecules to each R subunit causes the release of active C subunit [2] and leads to downstream cellular changes in the activity of transcription factors, enzymes, ion channels, and many other cellular substrates [3], [4].
Unlike many other CYP3A substrates, neither drug is significantly transported by p-glycoprotein.
It is likely that loss of GRASP65 protein would not impair apoptosis progression as, in its absence, many other Golgi substrates might take over and leads to Golgi fragmentation.
Once bound, Src can phosphorylate FAK on several residues including Y925 resulting in the further activation of FAK tyrosine kinase activity [ 3] and in the phosphorylation of many other cellular substrates.
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some other substrates
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many physiological substrates
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many other countries
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