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In addition, many other pathological states are associated with hyperuricemia, including metabolic syndrome, heart failure, pulmonary disorder and type 2 diabetes mellitus [68].
Although most of the attention has been focused on the role of these cells in the field of cancer research, accumulating evidence has indicated that MDSCs also regulate immune responses during many other pathological conditions such infection, autoimmunity and so on[31].
Lipid peroxidation causes damage to unsaturated fatty acids, which results in decreased membrane fluidity and leads to many other pathological events [ 4, 50].
Lipid peroxidation causes damage to unsaturated fatty acids, which results in decreased membrane fluidity and leads to many other pathological events.
Considering the widely acknowledged involvement of this pathway in cancer, diabetes and many other pathological conditions [ 42], a further study of the identified miRNAs is likely to yield insights into the molecular underpinning and possible biomarkers of these phenomena.
However, such small changes in copy number are important because they are characteristic of aneuploidies seen in utero, of cancer progression (where the loss of one copy of a gene can lead to formation of a tumor), and of many other pathological conditions [ 7].
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This important bioactive peptide is involved in the control of blood pressure and many other physiological and pathological processes.
This ability is a requirement for cell migration and tissue remodeling, both of which play essential roles in embryonic development, reproduction, tissue remodeling as well as many other physiological and pathological processes.
Having been studied for about a decade, miRNAs have been demonstrated to have important roles in development[7], [8], cell proliferation [9] [11], differentiation [12] [16], apoptosis[17], [18], cell cycle progression [19] [21], tumorigenesis[22] [26] and many other physiological or pathological processes[2], [16], [27].
Intact and impaired SL-related autophagy has significant implications for many other diseases and pathological processes.
In addition to tumors, the deficiency in oxygen supply and blood flow regulation accompany many other physiological and pathological states.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com