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Another factor of environmental exposure, alcohol, has been associated with many organ abnormalities and cognitive deficits.
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Finding mutations within such ncRNAs takes persistence; for example, a mutation affecting a ncRNA was reported recently in microcephalic osteodysplastic primordial dwarfism type I (MOPD I), a severe developmental disorder characterized by extreme intrauterine growth retardation and multiple organ abnormalities, after many years of careful genomic investigations [ 4].
It has been reported that extremely low levels of maternal peripheral 5-HT result in smaller mouse embryos that also exhibit abnormalities in many organ systems [ 60, 61].
Because WFS is a neurodegenerative disorder, most WFS patients suffer also from diabetes insipidus, deafness, and many other multi-organ abnormalities [ 9, 10].
Our results suggest that heterozygous mutation of dOpa1 shows organ-specific pathogenesis and is associated with multiple organ abnormalities in an age-dependent and organ-specific manner.
Accumulation of HS in lysosomes leads to progressive cerebral and systemic multiple organ abnormalities.
Olfactory bulb and reproductive organ abnormalities were observed in a proportion of Chd7 Whi /+ mice.
Organ abnormalities involved in the process of disability in older people are still incompletely understood.
ADPKD is a systemic disorder with cysts and connective tissue abnormalities involving many organs.
Since morphological abnormalities of many organs were observed in the occludin knockout mice, occludin is considered to be essential for maintaining the morphology of other organs (Saitou et al., 2000).
Acromegaly has various impacts on many organs.
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