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Many older studies report response rates in terms of clinical, radiological and biochemical response rather than according to WHO or RECIST criteria.
The log-linear dose response function for lead, especially if it generalizes across other health outcomes, may also account for the failure of many older studies to find significant lead-related effects.
Although other reviews of mapping studies have been conducted previously [ 3- 8], at least 40 studies have been published since even the most recent study [ 7] was conducted and many older studies are also omitted from these previous reviews.
Additionally, many older studies were based on semi-quantitative data obtained from visual rating scales to estimate SH load [ 63, 73- 75] or with the use of volumetric estimates derived by adding slice-by-slice semi-quantitative ratings with spherical shape assumptions for each lesion [ 76].
However, the publication of new studies and the fact that many older studies that were included in these former meta-analyses used obsolete radiation doses, CHX schedules or study designs prompted us to carry out a new analysis using strict inclusion criteria.
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Dr. Twenge decided to dig up as many old studies using the Bem survey that she could find, average out their scores by year and chart them over time.
Indeed, the sensitivity of mammalian adaptive immune responses to small quantities of flagellin initially led to the use of this antigen in many older immunological studies [ 6, 22, 23].
11 Many large older studies demonstrate satisfactory cure rates.
This result is surprising because it is inconsistent with many previous studies which shows older people are less likely to start-up business than young people (Hart et al., 2004; Lévesque and Minniti, 2006; Kautonen, 2008; Hatak et al., 2015).
Many of the older studies contained anecdotal evidence, and in many studies, fish were combined with other antimalarial interventions in uncontrolled designs, so attribution of an effect was not possible.
Second, comparisons could be hampered, because information about variances and means of traits are lacking in many, in particular older studies [8].
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