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MEG3 is a tumor suppressor long non-coding RNA being expressed in many normal tissues.
Finally, because expression of the CYP2E1 gene is very high in tumor tissues but low in many normal tissues, GA could therefore produce tissue-specific proteasome inhibition and tumor-specific toxicity, with clinical significance for designing novel strategies for cancer treatment.
P-gp is also expressed in many normal tissues, such as kidney, liver, intestine, placenta, and BBB.
However, drawing VOI for ADC evaluation was another problem due to the lack of anatomical information caused by the suppressed signal in many normal tissues in DWI [11].
NEP and IDE are metalloproteases widely expressed in many normal tissues; in the brain they are localized in areas vulnerable to amyloid deposition.
Amano et al. also studied the immunohistochemical expression of GGCT in many normal tissues [ 13].
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This strategy could be superior to targeting Pgp function as a low level of Pgp is expressed in many normal tissue cells such as liver, biliary tract, brain, kidney and intestines, which play roles in the excretion of toxins.
Interestingly, there were many normal tissue gene expression traits associated with DFS in the good DFS group, while many tumor tissue gene expression traits associated with DFS in the poor DFS groups (Additional File 3 Figure S2), again suggesting that the gene expression data may help stratify patients according to DFS beyond what could be achieved by the clinicopathologic parameters alone.
The precise actions of genes are frequently dependent on their tissue context, yet direct assay of tissue-specific protein function and interactions remains infeasible in many normal human tissues and cell-types.
CAR is ubiquitously expressed in many normal epithelial tissues, but its expression appears to vary in tumor tissues with advanced grade, stage and increased metastatic potential.
TIP30 is positively expressed in many normal human tissues but decreased expression is observed in some tumour tissues such as melanoma, breast cancer, neuroblastoma, glioblastoma, colon cancer and hepatocellular carcinoma (HCC).
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