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AREs regulate the expression of many genes at the post-transcriptional level, and they are essential for many normal cellular functions.
BRCA1 plays a multifunctional role and has been implicated in many normal cellular functions, including DNA damage response, transcriptional regulation, cell-cycle checkpoint control, and ubiquitination.
The consensus in the field is that protoplasts are impaired in many normal cellular functions.
They are involved in protein folding, assembly, stabilization, activation, and degradation in many normal cellular processes and under stress conditions.
Heat shock proteins (Hsps) are responsible for protein folding, assembly, translocation, and degradation in many normal cellular processes.
In addition, metabolic wastes may also over burden the cell cytoplasm that inhibits so many normal cellular functions and give rise to drug induced adverse effects.
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SH3 domains regulate many normal and pathological cellular processes by guiding specific protein interactions.
AP-1 transcriptional regulation is known to be involved in many normal and pathogenic cellular processes (13– 13).
DNA methylation is a crucial epigenetic modification involved in many biological processes, from normal cellular differentiation to disease genesis and progression.
Mitochondria are the site of many biochemical reactions fundamental for normal cellular functioning, particularly cellular energy production.
Many endocrine-active xenobiotics affect normal cellular and developmental processes in animal models, with the prostate being one sensitive target (Timms et al. 2005; vom Saal et al. 1997).
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