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Short synthetic peptides corresponding to the newly exposed N-terminal hexapeptide sequence also activate PAR2 on immunoinflammatory, cancer and many normal cell types.
Many normal cell and/or tissue behaviors are often co-opted by and for malignant cells.
In many normal cell types, glucose deprivation results in an increase in the maximum velocity of glucose transport (Kitzman et al, 1993).
While JNKs are attractive targets, they regulate in many normal cell functions, especially in matrix remodeling and host defense [ 23, 24].
However, since Akt is essential for many normal cell functions [ 24- 26], cell survival in particular, targeting Akt for cancer therapy is a bottle neck due to the serious side-effects associated with it.
However, there are many normal cell types that express ABC transporters at significant levels (e.g., bone marrow stem cells, brain capillary epithelial cells, epithelial barrier cells), and these might be subject to toxicity from the agents that induce collateral sensitivity.
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Standard chemotherapy uses drugs to destroy cancer cells, but also kills many normal cells, causing side effects like fatigue, hair loss, pain, nausea, and vomiting.
Since many normal cells express MMP-2, it is important to understand the mechanisms that may prevent its endogenous presentation.
In contrast, many normal cells ubiquitously express LAT2, the second system L isoform 5, 17.
It is well established that many normal cells require integrin-mediated adhesion to enter S phase of the cell cycle.
Syndecan-1, a transmembrane heparan sulphate proteoglycan, is expressed by many normal cells, including epithelial and endothelial cells.
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