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The investigators noted many new, specific and informative expression patterns.
Many new specific Notch inhibitors are under development, with 23 ongoing phase I/II clinical trials investigating the efficacy of GSIs (www.clinicaltrials.gov).gov
Molecular imaging is important to cancer research, diagnosis and therapy now because of the many new, specific therapies that may not be as indiscriminately cytotoxic as most have been to date.
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Many new brain-specific imprinted genes were recently reported from genome-wide analyses (Gregg et al., 2010a; Gregg et al., 2010b), although only a fraction have been independently validated (DeVeale et al., 2012).
Further, we inferred periodic activities of several less known transcription factors over the course of the cell cycle, identified over 500 putative regulatory targets and detected many new phase-specific and conserved cis-regulatory motifs.
If the inversion harbored many new mutations, these specific alleles would have been uncommon in the Ancestral population and then at intermediate frequency in both Low and High (based on the observed frequency of inversion haplotype).
To make it operational, many new associated and more specific concepts have been proposed such as natural and social capital, conservation economy and quality of life capital.
In Table 1 we list the most endothelial and pericyte enriched probe sets which provide many new endothelial and pericyte/VSM specific markers within the brain.
Finally, little is known about the cell biological consequences of many new agents that target different specific signalling pathways.
In routine clinical practice, general proteinuria and microalbuminuria are considered the best biomarkers of FD nephropathy [ 3], although, recently, many new markers, including Gb3 or specific proteins such as N-acetyl β-D-glucosaminidase and cystatin C, have been suggested to improve decision making [ 5].
Many new substances and drug delivery systems specific to the inner ear are under development and in some cases are being evaluated in animal experiments and in clinical studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com