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Perhaps that's because there are so many new agents.
Although many new agents have been developed aimed at putative molecular targets, recent breakthroughs in therapy for advanced disease have arisen from our ability to safely give patients combination cytotoxic chemotherapy.
Another part of failing to budget well is forgetting to pay Uncle Sam, said Andy Brown, principal of Climer, because many new agents are not used to it.
VICE News' David Noriega went to Arizona to meet with Art del Cueto, the vice president of the Border Patrol Union, and ask him why the patrol needs so many new agents.
Finally, little is known about the cell biological consequences of many new agents that target different specific signalling pathways.
But, even with treatment, outcomes remain dismal, and given this important unmet medical need, many new agents are currently in development for older patients with AML [ 41– 41].
Similar(42)
However, this has led to increased complexity among therapeutic agents, with many newer agents based on the use of cellular substances, the genetic modification of cells and tissues, and the administration of substances that act indirectly on target tissues by altering specific physiological functions in patients.
For new biological agents this is even less certain, although the success of trastuzumab suggests that we can have confidence that a model developed for untargeted cytotoxics, and loosely targeted hormonal therapies, may work out for many newer agents.
Many newer agents or approaches have been the focus of TRS studies with the hope of having similar efficacy to clozapine but better tolerability and safety – although, on average, other medications seem less effective than clozapine [ 8, 9].
Combinations of chemotherapy are the most effective in many settings, and many promising new agents are under active investigation or are being explored in preclinical models.
In addition to the agents listed in Table 1, many new biologic agents are currently in development (Chan and Behrens, 2013; Reichert, 2013; Yao et al., 2013).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com