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Because population size post self-renewal will be large, many mutations will be present and strong selection will produce many different compensatory alleles.
Therefore, no information is usually available on alternative splicing and many mutations will be missed [ 12].
This means that many mutations will not effect the phenotype and therefore will not be selected against.
Because many mutations will lead to loss of catalytic activity, the evolution of regulatory proteins from "dead" enzymes might be quite common.
Because healthy bacteria strains are critical for industrial purposes, using the mutator strain P. fluorescens ATCC948 to produce 6-aminopenicillanic acid or cholesterol esterase may not be optimal, as many mutations will be introduced into growing cells during the mass culturing process.
Similar(54)
B-SIFT produces scores in a way consistent with the expectation that many more mutations will be deleterious than activating.
Obviously, many nonsynonymous mutations will have been gradually eliminated due to their deleterious effect.
Furthermore, bacteria in biofilms have huge population sizes so that many new mutations will arise over relatively short time scales.
Many somatic mutations will be sufficiently close to heterozygous germline SNPs that individual sequencing read pairs will span both, thus allowing the mutation to be "phased" with the SNP.
However, it is also clear that many mutation carriers will be missed if the presence of a strong family history of breast cancer and/or ovarian cancer is used as the sole criterion to offer genetic testing.
But flus pick up many mutations, and there will be no proof of protection until the C.D.C. can test stored blood serum containing flu shotantibodies against the new virus.
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