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On average, fathers pass on at least six times as many mutations to their children as mothers.
Many mutations to nondetectability occurred.
Defects in the cell's mismatch repair tools can wreak havoc as this allows many mutations to accumulate.
Highly similar LTR sequences suggest that an element was only recently inserted, because too little time elapsed for many mutations to accumulate between them.
We did not want to find too many mutations to follow up as we are in an ultra-competitive CRISPR field.
Assessing the significance of rare or unique mutations across the genome to disease manifestation, particularly if these fail to converge on the same genes, will be difficult as there may be just too many mutations to identify which have a causal role.
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It appears that the degeneration of eyes is due less to the accumulation of many mutations than to mutations in a few, very specific, high-impact regulatory genes.
If a major group (e.g. Ehrhartoideae) is represented by only one species (e.g. rice), then DNA sequence(s) from that species will contain many mutations relative to all other species in the study.
Many mutations contribute to tumorigenesis by causing transcriptional deregulation through epigenetic modifications resulting in aberrant proliferation, impaired differentiation, and impaired apoptosis.
Many mutations lead to protected polymorphisms in which there is more than one male or female genotype at equilibrium (Table 3, Figure 4).
We note that this may also limit detection of RIP in TE sequences that have recently proliferated and therefore have not sustained many mutations due to RIP and other processes.
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