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The avian virus would need to accumulate many mutations in its genetic material before it could become a pandemic strain, said Yoshihiro Kawaoka, a virologist at the University of Tokyo and the University of Wisconsin.
Rosenberg believes that melanoma has a unique relationship with the immune system: there are so many mutations in the tumors that T-cells have an easier time recognizing them as foreign.
Although many mutations in the GH receptor have been identified, there have been only a few reports of deletions of the GH receptor gene.
These regions tend to be conserved over evolution, and scientists have thus assumed that too many mutations in these regions are fatal.
Previously, it has been shown that many mutations in the H-bond network around the protonation site, e.g., at positions D407, D408, K940, and T978, result in reduced transport activity.
Many mutations in cardiac troponin T (cTnT) lead to a complex form of HCM with varying degrees of ventricular hypertrophy and ~ 65% of all cTnT mutations occur within or flanking the elongated N-terminal TNT1 domain.
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Michael S. Watson, executive director of the American College of Medical Genetics, said that many mutations even in disease-causing genes do not produce serious or even detectable illness.
Although few TET2 recurrent mutations have been reported, many mutations result in a frameshift or early stop codon and are therefore inactivating (Tefferi et al., 2009b).
There are many mutations described in LRRK2, however unequivocal proof of causation only exists for a small number.
First, however, they will have to discern which of the many mutations seen in malignancies are bystanders and which are driving the out-of-control growth of cells.
There are many mutations reported in various studies as associated with drug resistance mechanisms.
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