Sentence examples for many mutations destabilise from inspiring English sources

Many mutations destabilise p53 and cause it to aggregate, with concomitant reduction or loss of function.

"The cells will carry as many mutations as we want to study.

"Many mutations in the mitochondria gradually dis-able the cell's energy production".

Many mutations to nondetectability occurred.

Both mutations destabilised L31W by similar amounts (2.2 and 2.6 kcal mol−1) indicating that the carboxylic acid group in the aspartate is forming a stabilising interaction.

We have previously shown that the positioning of this helix on the surface of Rap1GAP is apparently crucial for its function, as mutations destabilising its location have a dramatic effect on catalytic efficiency without having an effect on kcat.

Over-expression of the GST-A427D-UBA sequence led to rapid degradation in E. coli, consistent with the A427D mutation destabilising the three-helix bundle of the UBA monomer rendering the unfolded protein highly susceptible to proteolysis.

The IDH-2 mutation is just one of many enzyme mutations that are found in acute myelogenous leukemia.

But, like so many attempts to destabilise Ms Royal, it may end up boosting not discrediting her.

There are many serious mutations among insects due to the absence of public conveniences.

The defect results from one of many possible mutations in a very large gene.