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There are likely many more subtypes of the group of diseases known collectively as idiopathic arthritis than have as yet been defined by clinical criteria.
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Recent large-scale breast cancer genome studies have revealed that each molecular subtype has specific pattern of genomic alterations and notably, tumors of HER2-enriched and basal-like subtypes harbor many more rearrangements than the luminal A subtype, which primarily consists of receptor positive breast tumors [ 2].
Cancers are composed of many more histological types and subtypes and most anatomically defined cancers are much more heterogeneous than their properly differentiated normal tissue counterparts.
The luminal B subtype has only two subtype-specific pathways: Histidine metabolism and Phosphatidylinositol signaling systems, although it has many more enriched pathways than the luminal A subtype.
Soft tissue sarcomas (STS) are rare cancers of mesenchymal cell origin that include more than 50 histological subtypes, as well as many more molecularly distinct entities [ 1, 2].
This expansion is focused on interferon subtypes IFNW and IFND; pigs (p) and cattle (c) share novel subtypes of IFND (p), IFNT (c), IFNAW (p & c) and many more isoforms of IFNW.
The largest study to date, performed by the Molecular Taxonomy of Breast Cancer International Consortium METABRICC), suggests that many more putative driver events exist, with many of these being specific to certain breast cancer subtypes [ 4].
Many, many more.
Along with many, many more.
And more, many more places.
(Many more are "confidential").
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com