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(Stubb makes many more predictions at a given significance, however).
As can be seen, processing large CCS creates many more predictions with mostly better precision.
Many more predictions are possible, especially with respect to stratified therapies in dependence on patient characteristics.
It should be noted that there are many more predictions for CNM than MRESS SNPs.
In contrast to orthology-only, the combined approach creates many more predictions (2- to 50-times more).
Apart from being able to explain most of the known epidemiological patterns the hypothesis makes many more predictions that are potentially testable.
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It rather indicates that the combined method derives many more novel predictions that can not be validated during cross-validation rather than successfully reproducing known function for well-characterized proteins (see Discussion of predictions).
While the examples above do not exhaust the possibilities, and many more specific predictions about particular genes, signaling pathways, and NCC subtypes can be made, we hope that the short summary above shows that our hypothesis is not just compatible with a considerable body of existing research and data, but makes many testable predictions that can drive future research.
The results presented in Figure 2 and in Additional file 4 show that although the PWM-based method generated many more TFBS predictions as compared to RDM, the CpG "traffic lights" were significantly underrepresented in the TFBSs in 270 out of 279 TFs studied here (having at least one CpG "traffic light" within TFBSs as predicted by PWM), supporting our major finding.
Trying out a few predictions, the model seemed to be reasonably good at predicting outliers, understanding that articles about fluffy kittens are unlikely to attract abusive comments while those about feminism tend to garner many more, but any predictions about more 'normal' articles were just stabs in the dark.
Many of the motifs we discovered match known protein motifs and many more are novel predictions, suggesting that post-translational regulation is largely uncharted territory.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com