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Soon, by exposing large numbers of seeds and young plants, scientists produced many more mutations and found a few hidden beneficial ones.
Alternatively, the strains of N2 sequenced by the genome consortium had accumulated many more mutations than our N2 stock.
B-SIFT produces scores in a way consistent with the expectation that many more mutations will be deleterious than activating.
Both approaches have identified many more mutations that selectively affect fertility in males than in females.
For example, many more mutations are deleterious rather than advantageous [ 15, 16].
Rodent species accumulate many more mutations within a defined time frame than larger mammals [ 27, 28].
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This suggests that there are many more dominant mutations than recessive (classic tumour suppressor) mutations, and that mutation plus loss of heterozygosity of tumour suppressor genes makes a very small contribution to the development of breast and colorectal cancer.
Furthermore, protein coding RNAs are resistant to frame shifts and they have many more silent mutations than other parts of genome; such observations which can be used towards the discovery of protein coding genes are not valid for ncRNA genes.
Many more inactivating mutations were subsequently found, accounting for ∼25% of FGD cases.
As most TF binding of the factors we profiled occur outside of proximal promoters, it is likely that many more human mutations that regulate genes through long-range interactions remain to be found.
Furthermore many more phage mutations escaping CRISPR recognition occur in the PAM compared to in the protospacer sequence (e.g., in [ 45] of 15 escape mutants, two had mutations only in the protospacer region, twelve only in the PAM and one in both).
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CEO of Professional Science Editing for Scientists @ prosciediting.com