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In particular, virtual screening allows us to evaluate many more compounds and biological targets than we can test experimentally, helping to identify starting points for further development.
Indeed, biosensor systems involving β-galactosidase-expressing freeze-dried recombinant bacteria could prove useful for the in situ detection of many more compounds in the future.
Many more compounds derived from berberine, tacrine, artemisnin, quinine, NSAIDs, pralidoxine, donepezil, rivastigmine, curcumin and various antioxidants are under investigations for exploration of their multifunctional potential.
Here, I provide evidence that suggests that modern medicinal chemists are overproductive in that they synthesise many more compounds than are required to achieve the objectives of the project.
Ellman's team synthesized about 4000 oxime pairs and found a handful of powerful Src inhibitors, a hit rate that typically requires many more compounds.
Other components are hemicellulose, extractives, lipids, proteins, simple sugars, starches, water, hydrocarbons, ash and many more compounds that contain a variety of functional groups present in the binding process.
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Many more chemical compounds are available from university chemists.
But Gonzalez cautions that smoked cannabis contains many more active compounds than THC does, and they may also be involved in harming the memory and other side effects.
Room temperature aqueous extraction experiments using endemic area Pliocene lignite samples produced many more organic compounds and in greater concentrations than bituminous coals run under identical conditions (Fig. 2).
For the antimicrobial activities of Lysobacter species other than L. enzymogenes, however, only few corresponding metabolites and their biosynthetic genes are known and many more bioactive compounds remain to be discovered.
Room temperature experiments using an endemic area Pliocene lignite sample also produced many more organic compounds and in greater concentrations than nonendemic area lignites from Romania and the USA run under identical conditions (Fig. 3).
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CEO of Professional Science Editing for Scientists @ prosciediting.com