Many molecules implicated in migratory polarity show uniform cellular distribution under non-activated conditions, but acquire a polarized localization upon exposure to migratory cues.
CK2 is a highly pleiotropic protein kinase which recognizes seryl and threonyl residues specified by an acidic side chain at position n + 3, whose seemingly endless repertoire of substrates includes many molecules implicated in protein synthesis, folding, and degradation (19).
Since many of the molecules implicated in this process are major players in important intracellular signalling events, this question is of considerable interest to a general audience.
To enhance cancer cell apoptosis and thus overcome treatment failure, many therapeutic strategies targeting other molecules implicated in apoptosis resistance have been developed [ 95, 96].
Sphingolipids are a diverse class of signaling molecules implicated in many important aspects of cellular biology, including growth, differentiation, apoptosis, and autophagy.
There is an extensive literature, however, investigating the relationship between many of the cytokines and effector molecules implicated in the various pathological processes associated with the development and progression of SSc [11], [12], [13], [14], [15].
Similarly, many proteins found in the midgut are only synthesized by blood-feeding females [ 3, 21]: numerous digestive and proteolytic molecules implicated in blood digestion were identified as female elevated in our analysis.
In contrast to past trial-and-error discovery, we are starting to see designer drugs that target known sites on molecules implicated in disease.
Another group of signaling molecules implicated in mediating Notch pathway activation are mitogen-activated protein kinases (MAPKs) (Hu et al., 2008; Zeng et al., 2005), a family of serine/threonine protein kinases many of which are key regulators of inflammation.
α-Neurexins are essential synaptic adhesion molecules implicated in autism spectrum disorder and schizophrenia.
Angiopoietin-1 (Ang-1) and -2 (Ang-2) are molecules implicated in angiogenesis and regulation of endothelial permeability.
