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The synthesis of small bioactive molecules mimicking the activity of endogenous hormones allows us to unveil many molecular features of their functioning, giving rise to a new field, plant chemical biology.
This has been possible because the zebrafish skeletal muscle has many molecular features (i.e. a conserved transcriptional network regulating myogenesis), as well as histological and ultrastructural features, that are very similar to those in the mammalian muscle [ 12, 13].
Moreover, we show that fibroblasts activated by serum in vitro share many molecular features with the fibroblasts that are naturally and abundantly present within primary human breast cancers and metastases.
Further, more recent studies of Neve and colleagues [ 32] have demonstrated that the MDA-MB-435 cell line shares many molecular features with breast cancer cell lines of breast epithelium origin.
In optimizing the human ACHE-S gene sequence, we took a preemptive approach: modifying many molecular features that might have otherwise proven deleterious to the expression of the transgene or to the accumulation of its product.
Given that the majority of C-LTMRs-enriched genes were also expressed in NF200+ neurons and that NF200 is a hallmark of proprioceptive and Aβ and Aδ LTMRs (Abraira and Ginty, 2013), we postulate that C-LTMRs share many molecular features with some Aβ and Aδ LTMRs.
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Breast cancer represents a heterogeneous disease with many distinct molecular features.
Our sequence data showed many unique molecular features, which can provide valuable information for studying problems of mitochondrial genome evolution, for example, the mechanisms of mitochondrial gene rearrangements, truncation of tRNA secondary structures, and nucleotide frequency bias.
Here we show that a small set of transcription factors can convert adult human fibroblasts into Best1::GFP positive cells, which bear many morphological and molecular features of RPE such as the expression of Mitf, Best1, Cralbp, and Tyrp2.
Since first described in a rodent model in 1987, aberrant crypt foci (ACF) in the colon have been shown to exhibit many of the molecular features of the more advanced colonic neoplasms including cancer.
Recent research has shown that the similarity of O3-induced cell death and hypersensitive cell death is not only external [2], [40] since these phenomena also share many physiological and molecular features [3], [11].
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