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Each mammalian cell contains thousands of mitochondria containing many mitochondrial nucleoids, and each mitochondrial nucleoid contains 2 10 copies of mtDNA (Shadel, 2008).
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A major component of mitochondrial nucleoids [ 64, 69, 70].
We show that the MRGs are distinct from mitochondrial nucleoids.
Importantly, mitochondrial nucleoids are also located in the inner mitochondrial membrane (IMM), and the PHB complex is a peripheral component of mitochondrial nucleoids [ 92].
Quantitative analysis indicated that mitochondrial nucleoids are associated with over 80% of mitochondrial division events.
Previous data have demonstrated that ERMES localizes with a subset of actively replicating mitochondrial nucleoids.
Unfortunately, mitochondrial nucleoids from fission yeast cells have not yet been studied.
As discussed above, the disorganization of mitochondrial nucleoids by PHB1 or PHB2 depletion leads to disturbed mitochondrial biogenesis.
A subset of mitochondrial nucleoids, specifically those that are actively replicating, co-localize with the ERMES complex [ 47].
Thus, we postulate that ER-associated division serves to link the distribution of mitochondria and mitochondrial nucleoids in cells.
These results indicate that the lack of Abf2 in mitochondrial nucleoids increases polymerase slippage events during mtDNA replication, and this defect might lead to mitochondrial genome rearrangements.
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