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A review of the studies of behavioral treatment of headache [67] reports a 35 55% improvement but also emphasizes many methodological imperfections, including selection bias, credibility of the control procedure, and lack of reproducibility of the results.
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Many methodological biases preclude conclusive information.
Over the years, experienced palaeographers have devised many methodological approaches to writer identification.
However, the evaluated RCTs had many methodological shortcomings.
There are still many methodological problems with respect to epidemiological studies about the migraine [3 7].
In addition, there seemed to be methodological imperfections in the direct and indirect methods.
At this moment, studies reviewing early PoC markers are characterised by methodological imperfections [ 37].
There is also empirical evidence in medicine on how methodological imperfections in a randomized trial can influence effect estimates, which usually become exaggerated (12).
Unfortunately, the studies have many methodological limitations.
Reconstructing molecular mechanisms in cancer on the basis of modules, networks, and complexes is a formidable challenge both because of the enormous numbers of components in interacting networks but also because of inherent difficulties arising from methodological imperfections.
Many methodological requirements for a high quality trial are met.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com