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These genes included many metabolic system- and immune system-related genes.
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The bow tie structure is already known to characterize many metabolic and system networks and it is recognized as a topological feature which provides robustness to systems [ 33, 50].
Furthermore, it is important to match the type of validation as to how the testing system will be used (Unnithan et al. 1994), and although many automated metabolic systems are used on pediatric/adolescent populations, few systems have been actually validated using these groups (Unnithan et al. 1994).
Active degradation of proteins or mRNA is a major part of many metabolic and stress response systems [ 11].
Thousands of studies have shown that mercury affects many metabolic processes and organ systems in humans and experimental animals.
This approach is sufficient for small networks but for large networks comprising many metabolic reactions an information storage system is required.
Examples include the cobalamin pathway, many metabolic transporters and iron uptake systems.
The HNF4α regulation of many genes involved in metabolism agrees with the notion that the transcriptional activity of HNF4α is regulated by AMP-activated protein kinase, the central component of a cellular signaling system that regulates many metabolic enzymes and pathways in response to reduced intracellular energy levels [ 34].
Finally, some of the many neutral mutants might mutate to something that potentially carries some utility for the metabolic system itself – and that something might be many different things.
A system of regulatory molecules interacts at the cellular level to control and coordinate the many metabolic pathways that constitute normal mineral metabolism.
This means that many neutral mutants of different sequences accumulate within the metabolic system as new mutations occur.
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